Cambridge Healthtech Institute’s 8th Annual
Advances in Recovery and Purification – Parts 1 and 2
19-20 March 2024
Cambridge Healthtech Institute’s 8th Annual Recovery and Purification conference brings together leading downstream processing (DSP) experts from industry and academia to explore the latest advancements in the capture, recovery, and purification of biotherapeutics across a range of modalities and development phases. How do your processes compare?
Taking place across 3 days, topics include: latest developments in chromatography, resins, digitalisation and process modelling, automation, continuous processing, PAT and digital twins, high-throughput process development (HTPD), innovative membranes, removing impurities, and emerging novel purification techniques.
Part One will highlight traditional biotherapeutic modalities such as antibodies, vaccines, multispecifics, conjugated products such as antibody-drug conjugates (ADCs); with Part Two focusing on DSP for novel modalities such as viral vectors, lipid nanoparticles, RNA-based therapies. Major themes include digitalisation, process modelling, continuous processing, and sustainable approaches across the supply chain.
Coverage will include, but is not limited to:
Latest Industry Trends in Downstream Processing
- Keynote: what are the current challenges in downstream processing: emerging modalities, technologies, and industry pressures on DSP
- New technologies and global pressures
- Sustainability in process development—DSP supply chain
Advances in Recovery and Purification
- Novel approaches to DSP—new technologies, modelling
- New ligands, affinity technologies, membrane technologies
- 3D-printed approaches for purification
- New approaches and platforms for purification
- HTPD models for improving DSP—resin screens
- Removing host cell proteins
DSP for Bispecifics, Multispecifics
- Purification strategies for emerging modalities—multispecifics, bispecifics, T cell engagers, fusion proteins
- Platform development for diverse pipelines—impact of protein engineering on PD
- Formulation strategies for multispecifics
- DSP for PEGylated therapies
- Examples from nanobodies
DSP for Antibody-Drug Conjugates
- Process development for antibody-drug conjugates—linkers, non-chromatographic purification
- Challenges of purifying highly potent therapies
- Characterisation and control of impurities in ADCs
Digitalisation, Process Modelling
- Role of data to enhance decision-making in DSP
- Digital twins—case studies
- PAT and process modelling—advances in raman and outcomes
- Predictive modelling for real time monitoring
- Mechanistic modelling for predicting processes
ML/AI Approaches in Bioprocessing
- ML strategies to optimise chromatography, DSP modelling
- What could a GEN AI bioprocessing look like?
- GEN AI approaches in process development—thoughts and strategies
DSP for Viral Vectors, mRNA, LNPs, Exosomes, RNA, Nanobodies
- Recovery and purification of viral vectors—new resins, increasing yield, overcoming challenges in full/empty
- Purification of mRNA/ LNPs
- Purification of antisense oligonucleotides
- Purification technologies for exosomes
Process Development of Microbial-Based Systems
- Process development of microbial-based systems—upstream and downstream
- DSP for microbial-based systems
Process Development for VLPs
- Production of virus-like particles
- Purification of virus-like particles
The deadline for priority consideration is Friday 13 September
All proposals are subject to review by session chairpersons and/or the Scientific Advisory Committee to ensure the overall quality of the conference program. Additionally, as per Cambridge Healthtech Institute policy, a select number of vendors and consultants who provide products and services will be offered opportunities for podium presentation slots based on a variety of Corporate Sponsorships.
Opportunities for Participation: